P-51: Effects of Garlic on Sperm Parameters in Rats with High Fat Diet

Background: Obesity and raised body mass index (BMI) is a major risk factor for several diseases such as cardiovascular disease, type 2 diabetes, as well as gynecological problems. In recent years, some studies have associated the BMI with reproductive parameters in men, showing that increased BMI is related to poor semen quality, decreased sperm concentration, decreased and normal-motile sperm cells. Therefore, in this study effect of garlic on sperm parameters in high fat diet rats has been evaluated. Materials and Methods: Matured wistar albino male rats were divided to 3 groups, control with standard diet, high-fat diet group and high-fat diet with garlic. After three months, the rats were sacrificed and sperm parameters such as sperm count, motility, morphology and viability were analyzed. Results: Our results revealed that sperm motility in rats with high fat diet decreased compare to control sperms. Progressive stage of sperm motility was lower in group II (30%) rather than group I and III (35.36% and 49%, respectively). Sperm number of group II (55.75 × 106 per ml) was lower than group I (57 × 106 per ml) and group III (61.60 × 106 per ml) as well, but, there was not observed any significant differences in other sperm parameters such as sperm viability and normal morphology among three groups. Conclusion: The results of this study show that high fat diet result in sperm motility reduction significantly and feeding with garlic could increase and improve sperm motility in fatty rats.